Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity
نویسندگان
چکیده
منابع مشابه
Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells.
Changes in the peptide and MHC molecules have been extensively examined for how they alter T cell activation, but many fewer studies have examined the TCR. Structural studies of how TCR differences alter T cell specificity have focused on broad variation in the CDR3 loops. However, changes in the CDR1 and 2 loops can also alter TCR recognition of pMHC. In this study we focus on two mutations in...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2018
ISSN: 0021-9258
DOI: 10.1074/jbc.m117.814152